Metacyclini Chloridum Capsules
【DRUG NAME】generic name: Metacyclini Chloridum Capsules
【INGREDIENTS】The main composition is metacyclini chloridum.
【PHARMACOLOGY & TEXICOLOGY】Metacyclini chloridum belongs to
tetracycline antibiotics, but some tetracycline and
Oxybicycline-resistant strains are still sensitive to it. The
following organisms are susceptible to Metacyclini chloridum:
Rickettisia, Mycoplasma, Chlamydozoon, some atypical mycobacteria,
spirochaetes, Actinomyces, anthrax bacteria, Listeria
monocytogenes, fusiform shaped bacillusNocadia Vibrion, Brucella,
Flectobacillus, Yersinia, and etc. Enterococci is not sensitive to
Metacyclini chloridum. Metacyclini chloridum have some
antibacterial activity against Neisseria gonorrhoeae, but is not
active against penicillin-resistant gonococcus. Owing to wide use
of tetracycline antibiotics for years, the resistance of common
pathogenic bacteria（including some Gram-positive bacteria such as
staphylococci and most Enterobacteriaceae） to Metacyclini chloridum
is very severe. Cross drug fast exists between Metacyclini
chloridum and other tetracyclines. Mechanism of action :It is
combined with A place of 30S subunit of bacterial ribosome, thus
restraint chain propagation and influence the synthesis of
【INDICATIONS】1. Metacyclini chloridum can be used as first choice
drug or an alternative for the treatment of the following diseases:
rickettsial diseases including epidemic typhus, endemic typhus,
Rocky Mountain Spotted feverakamushi disease, Q fever.
(3) Chlamydozoon infections including parrot fever, adenitis
trophicalis, nongonococcal urethritis, salpingitis, cervicitis and
(4) relapsing fever.
(7) deer fly disease.
(8) anthracia pestis.
(9) chancroidal ulcer.
It is used together with aminoglycosides for the treatment of
brucellosis anthracia pestis.
2.it is only indicated when pathogenic bacteria is sensitive to it
because of the severe resistance of present pathogenic bacteria to
metacyclini chloridum. It is unsuitable for the treatment of
hemolytic streptococcal infection and staphylococcal infection.
3.In patients hypersensitive to penicillin, it is applied to treat
tetanus, emphysematous phlegmon, omunono, syphilis, gonococcal
urethritis, cervicitis, hepatic typhus, Actinomyces and Listeria
4.It can be used as adjunctive therapy of midrange and severe acne.
【DOSAGE AND ADMINISTRATION】For adults:300mg (1.5 tablet) to be
taken orally every 12 hours. For children over 8 years: 5mg/kg
(weight) every 12 hours.
【 STORAGE】Keep tightly closed and store in a dry and cool place.
【 PACKAGE】6 tablets×2 blister in PVC/aluminium packaging.
【 SHELF LIFE 】2 years.