|Boiling point||bp4 180-182°; bp2 159-160°|
|density||0.9944 (rough estimate)|
|Autoignition Temperature||>365 °C|
|Water Solubility||practically insoluble|
Lidocaine is also the most important class-1b antiarrhythmic drug;
it is used intravenously for the treatment of ventricular
arrhythmias (for acute myocardial infarction, digoxin poisoning,
cardioversion, or cardiac catheterization) if amiodarone is not
available or contraindicated. Lidocaine should be given for this
indication after defibrillation, CPR, and vasopressors have been
initiated. A routine prophylactic administration is no longer
recommended for acute cardiac infarction; the overall benefit of
this measure is not convincing.
Inhaled lidocaine can be used as an antitussive (cough suppressor)
acting peripherally to reduce the cough reflex. This application
can be implemented as a safety and comfort measure for patients who
have to be intubated, as it reduces the incidence of coughing and
any tracheal damage it might cause when emerging from anesthesia.
Lidocaine, along with ethanol, ammonia, and acetic acid, has also
been proven to be effective in treating jellyfish stings, both
numbing the affected area and preventing further nematocyst
Lidocaine is a local anesthetic, also known as sicaine, has been
replaced in recent years, procaine, widely used in cosmetic plastic
surgery in local infiltration anesthesia, can inhibit the nerve
cell membrane sodium channel blocking nerve excitability and
Conduction. Lidocaine lipophilic and protein binding rate is higher
than procaine, cell penetration ability, rapid onset, the role of a
long time, the interaction intensity is 4 times that of procaine.
Lidocaine for infiltration anesthesia, epidural anesthesia, local
anesthesia (including thoracoscopy or abdominal surgery for mucosal
anesthesia) and nerve block. In order to extend the time of
anesthesia, reduce the side effects of lidocaine poisoning, can
join anesthesia adrenaline.
Lidocaine can also be used to treat ventricular arrhythmias caused
by acute myocardial infarction, ventricular tachycardia, digitalis
poisoning, cardiac surgery and cardiac catheterization, including
ventricular premature beats, ventricular tachycardia and
ventricular fibrillation Premature beats. Lidocaine is also used
for status epilepsy, other antiepileptic drugs are ineffective, and
local anesthesia or spinal anesthesia. But is usually ineffective
for supraventricular arrhythmias.
Thus, lidocaine is suitable for osmotic, obstructive and topical
anesthesia. Long-acting substances such as bupivacaine are
sometimes given priority to subdural and epidural anesthesia. On
the other hand, lidocaine has the advantage of rapid onset.It can prevent adrenaline vasoconstriction, the formation of
bleeding, can also delay the absorption
Lidocaine, the duration of anesthesia almost doubled.
1: For block anesthesia and epidural anesthesia.
2: Also used for ventricular arrhythmias caused by myocardial
infarction, digitalism, glucantime poisoning, surgery and so on.
Such as ventricular tachycardia, frequent ventricular premature
beat, ventricular fibrillation.
3: As painkillers of injection in the medicament.
4: Also used in suppository and ointment preparation, etc.
Before use Lidocaine, you should care
Before using lidocaine, tell your doctor or pharmacist if you are
allergic; or other amide anesthetics (eg bupivacaine, prilocaine);
or if you have any other allergies. This product may contain
inactive ingredients that can cause allergic reactions or other
problems. Talk to your pharmacist more details.
Before using this medication, tell your doctor or pharmacist your
history, especially: lidocaine use the area of skin / infection,
heart disease, liver disease.
When children use this drug, it is recommended that they may be
more sensitive to the side effects of the drug.
During pregnancy, this medicine is used only when it is clearly
needed. Talk to your doctor about risks and benefits ...
Indications and Usage
Lidocaine hydrochloride injection,USP is indicated for production
of local or regional anesthesia by infiltration techniques such as
percutaneous injection and intravenous regional anesthesia by
peripheral nerve block techniques such as brachial plexus and
intercostal and by central neural techniques such as lumbar and
caudal epidural blocks,when the accepted procedures for these
techniques as described in standard textbooks are observed.
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